Pseudomonas aeruginosa PAO1, PA0538 (dsbB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0538
Name
dsbB
Replicon chromosome
Genomic location 596970 - 597479 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249229.1
GI 15595735
Affymetrix PA0538_dsbB_at
DNASU PaCD00006230
Entrez 878500
GenBank AAG03927.1
INSDC AAG03927.1
NCBI Locus Tag PA0538
protein_id(GenBank) gb|AAG03927.1|AE004490_7|gnl|PseudoCAP|PA0538
TIGR NTL03PA00539
UniParc UPI00001298B6
UniProtKB Acc P57701
UniProtKB ID DSBB2_PSEAE
UniRef100 UniRef100_Q02TM7
UniRef50 UniRef50_Q02TM7
UniRef90 UniRef90_Q02TM7

Product

Feature Type CDS
Coding Frame 1
Product Name
disulfide bond formation protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 3.31
Kyte-Doolittle Hydrophobicity Value 0.985
Molecular Weight (kDa) 18.1
Isoelectric Point (pI) 8.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 102 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000522 (302 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0538
Search term: dsbB

References

Identification and characterization of the Escherichia coli gene dsbB, whose product is involved in the formation of disulfide bonds in vivo.
Missiakas D, Georgopoulos C, Raina S
Proc. Natl. Acad. Sci. U.S.A. 1993 Aug;90(15):7084-8
PubMed ID: 7688471
Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation.
Jander G, Martin NL, Beckwith J
EMBO J. 1994 Nov;13(21):5121-7
PubMed ID: 7957076