Pseudomonas aeruginosa PAO1, PA0849 (trxB2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0849
Name
trxB2
Replicon chromosome
Genomic location 927880 - 928830 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_249540.1
GI 15596046
Affymetrix PA0849_trxB2_at
Entrez 882024
GenBank AAG04238.1
INSDC AAG04238.1
NCBI Locus Tag PA0849
protein_id(GenBank) gb|AAG04238.1|AE004520_1|gnl|PseudoCAP|PA0849
TIGR NTL03PA00850
UniParc UPI00000C5188
UniProtKB Acc Q9I592
UniProtKB ID Q9I592_PSEAE
UniRef100 UniRef100_W0YL93
UniRef50 UniRef50_Q4K9V2
UniRef90 UniRef90_Q02I08

Product

Feature Type CDS
Coding Frame 1
Product Name
thioredoxin reductase 2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.20
Kyte-Doolittle Hydrophobicity Value -0.015
Molecular Weight (kDa) 33.5
Isoelectric Point (pI) 5.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 656 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000816 (927 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0849
Search term: trxB2

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.
Waksman G, Krishna TS, Williams CH, Kuriyan J
J. Mol. Biol. 1994 Feb;236(3):800-16
PubMed ID: 8114095