Pseudomonas aeruginosa PAO1, PA0944 (purN)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0944
Name
purN
Replicon chromosome
Genomic location 1032095 - 1032763 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249635.1
GI 15596141
Affymetrix PA0944_purN_at
DNASU PaCD00006432
Entrez 878144
GenBank AAG04333.1
INSDC AAG04333.1
NCBI Locus Tag PA0944
protein_id(GenBank) gb|AAG04333.1|AE004528_11|gnl|PseudoCAP|PA0944
TIGR NTL03PA00945
UniParc UPI00000C51D0
UniProtKB Acc Q9I514
UniProtKB ID Q9I514_PSEAE
UniRef100 UniRef100_Q9I514
UniRef50 UniRef50_P08179
UniRef90 UniRef90_Q9I514

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylaminoimidazole synthetase
Product Name Confidence: Class 2
Synonyms phosphoribosylformylglycinamidine cyclo-ligase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.06
Kyte-Doolittle Hydrophobicity Value -0.334
Molecular Weight (kDa) 24.7
Isoelectric Point (pI) 7.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 615 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000910 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0944
Search term: purN

Human Homologs

Ensembl 94, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 6.3e-48
Percent Identity: 48.7

References

Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.
Almassy RJ, Janson CA, Kan CC, Hostomska Z
Proc. Natl. Acad. Sci. U.S.A. 1992 Jul;89(13):6114-8
PubMed ID: 1631098