Pseudomonas aeruginosa PAO1, PA1272 (cobO)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1272
Name
cobO
Synonym: btuR
Synonym: cobA
Replicon chromosome
Genomic location 1383718 - 1384329 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249963.1
GI 15596469
Affymetrix PA1272_cobO_at
Entrez 881408
GenBank AAG04661.1
INSDC AAG04661.1
NCBI Locus Tag PA1272
protein_id(GenBank) gb|AAG04661.1|AE004557_2|gnl|PseudoCAP|PA1272
TIGR NTL03PA01273
UniParc UPI00000C52E1
UniProtKB Acc Q9I472
UniProtKB ID COBO_PSEAE
UniRef100 UniRef100_Q9I472
UniRef50 UniRef50_Q9I472
UniRef90 UniRef90_Q9I472

Product

Feature Type CDS
Coding Frame 1
Product Name
cob(I)alamin adenosyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.69
Kyte-Doolittle Hydrophobicity Value -0.335
Molecular Weight (kDa) 22.3
Isoelectric Point (pI) 7.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 361 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001219 (549 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1272
Search term: cobO

References

Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation.
Lundrigan MD, Kadner RJ
J. Bacteriol. 1989 Jan;171(1):154-61
PubMed ID: 2644187
Purification and partial characterization of Cob(I)alamin adenosyltransferase from Pseudomonas denitrificans.
Debussche L, Couder M, Thibaut D, Cameron B, Crouzet J, Blanche F
J. Bacteriol. 1991 Oct;173(19):6300-2
PubMed ID: 1917862
Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium.
Suh S, Escalante-Semerena JC
J. Bacteriol. 1995 Feb;177(4):921-5
PubMed ID: 7860601