Pseudomonas aeruginosa UCBPP-PA14, PA14_05540 (mexB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_05540
Name
mexB
Replicon chromosome
Genomic location 487942 - 491082 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 23 transposon mutants in orthologs

Cross-References

RefSeq YP_788600.1
GI 116054157
Entrez 4384294
INSDC ABJ15393.1
NCBI Locus Tag PA14_05540
UniParc UPI000012F022
UniProtKB Acc Q02TY6
UniProtKB ID Q02TY6_PSEAB
UniRef100 UniRef100_P52002
UniRef50 UniRef50_P52002
UniRef90 UniRef90_P52002

Product

Feature Type CDS
Coding Frame 1
Product Name
RND multidrug efflux transporter MexB
Synonyms
Evidence for Translation
Charge (pH 7) -9.89
Kyte-Doolittle Hydrophobicity Value 0.274
Molecular Weight (kDa) 112.8
Isoelectric Point (pI) 5.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
adeF AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH. ARO:3000777 protein homolog model Strict 762.7 41.62 3.0.1

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3W9I MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters PSEUDOMONAS AERUGINOSA 2.71 X-RAY DIFFRACTION 100.0
3W9J MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters PSEUDOMONAS AERUGINOSA 3.15 X-RAY DIFFRACTION 100.0
2V50 MEMBRANE PROTEIN 10/01/08 The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB PSEUDOMONAS AERUGINOSA PA01 3.0 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2150 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_05540
Search term: mexB

References

No references are associated with this feature.