Pseudomonas aeruginosa UCBPP-PA14, PA14_21620 (oprP)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_21620
Name	oprP
Replicon	chromosome
Genomic location	1874675 - 1875997 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	10 transposon mutants in orthologs

Cross-References

RefSeq	YP_789875.1
GI	116051293
Entrez	4381278
INSDC	ABJ12529.1
NCBI Locus Tag	PA14_21620
UniParc	UPI0000E44998
UniProtKB Acc	Q02QB1
UniProtKB ID	Q02QB1_PSEAB
UniRef100	UniRef100_W0YWX3
UniRef50	UniRef50_P05695
UniRef90	UniRef90_P05695

Product

Feature Type	CDS
Coding Frame	1
Product Name	phosphate-specific outer membrane porin OprP precursor
Synonyms
Evidence for Translation
Charge (pH 7)	-6.06
Kyte-Doolittle Hydrophobicity Value	-0.447
Molecular Weight (kDa)	48.2
Isoelectric Point (pI)	5.21

Subcellular localization

Individual Mappings	Localization Confidence PMID Outer Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
2O4V	MEMBRANE PROTEIN	12/05/06	An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane	Pseudomonas aeruginosa PAO1	1.94	X-RAY DIFFRACTION	99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DB04233	DrugBank	5.1.4	P05695	Porin P	99.8	440	1.1e-255

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 48 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002334 (687 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_21620 Search term: oprP Search term: phosphate-specific outer membrane porin OprP precursor

Human Homologs

References