Pseudomonas aeruginosa UCBPP-PA14, PA14_25000

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_25000
Name
Replicon	chromosome
Genomic location	2185465 - 2187393 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	4 transposon mutants in orthologs

Cross-References

RefSeq	YP_790152.1
GI	116051021
Entrez	4384439
INSDC	ABJ12257.1
NCBI Locus Tag	PA14_25000
UniParc	UPI0000E449E0
UniProtKB Acc	Q02PI4
UniProtKB ID	Q02PI4_PSEAB
UniRef100	UniRef100_S0IHA9
UniRef50	UniRef50_L8MR62
UniRef90	UniRef90_A0A022P9S3

Product

Feature Type	CDS
Coding Frame	1
Product Name	lytic transglycosylase
Synonyms
Evidence for Translation
Charge (pH 7)	18.29
Kyte-Doolittle Hydrophobicity Value	-0.418
Molecular Weight (kDa)	73.3
Isoelectric Point (pI)	9.77

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6FCR	LYASE	12/21/17	The X-ray Structure of Lytic Transglycosylase Slt inactive mutant E503Q from Pseudomonas aeruginosa in complex with NAG-NAMtetrapeptide-NAG-anhNAMtetrapeptide	Pseudomonas aeruginosa	2.75	X-RAY DIFFRACTION	93.8
6FCU	LYASE	12/21/17	The X-ray Structure of Lytic Transglycosylase Slt inactive mutant E503Q from Pseudomonas aeruginosa in complex with 4(NAG-NAMpentapeptide)	Pseudomonas aeruginosa	3.2	X-RAY DIFFRACTION	93.8
6FCQ	LYASE	12/21/17	The X-ray Structure of Lytic Transglycosylase Slt inactive mutant E503Q from Pseudomonas aeruginosa in complex with Bulgecin A	Pseudomonas aeruginosa	3.1	X-RAY DIFFRACTION	93.8
6FC4	LYASE	12/20/17	The X-ray Structure of Lytic Transglycosylase Slt inactive mutant E503Q from Pseudomonas aeruginosa	Pseudomonas aeruginosa	3.05	X-RAY DIFFRACTION	93.8
6FCS	LYASE	12/21/17	The X-ray Structure of Lytic Transglycosylase Slt inactive mutant E503Q from Pseudomonas aeruginosa in complex with NAG-NAMpentapeptide-NAG-NAMpentapeptide	Pseudomonas aeruginosa	2.9	X-RAY DIFFRACTION	93.8
5OHU	LYASE	07/18/17	The X-ray Structure of Lytic Transglycosylase Slt from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.2	X-RAY DIFFRACTION	94.1
6FBT	LYASE	12/19/17	The X-ray Structure of Lytic Transglycosylase Slt from Pseudomonas aeruginosa in complex with the reaction product NAG-anhNAMpentapeptide	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	2.5	X-RAY DIFFRACTION	93.9

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 400 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002562 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_25000 Search term: lytic transglycosylase

Human Homologs

References