Pseudomonas aeruginosa UCBPP-PA14, PA14_25900

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_25900
Name
Synonym: enoyl-acyl-carrier protein reductase FabV
Replicon chromosome
Genomic location 2258754 - 2259950 (+ strand)
Comment

Cross-References

RefSeq YP_790223.1
GI 116050952
Entrez 4384331
INSDC ABJ12188.1
NCBI Locus Tag PA14_25900
UniParc UPI00000C58A0
UniProtKB Acc Q02PB3
UniProtKB ID Y2590_PSEAB
UniRef100 UniRef100_B7V2Z1
UniRef50 UniRef50_Q9PCE6
UniRef90 UniRef90_B7V2Z1

Product

Feature Type CDS
Coding Frame 1
Product Name
fabV
Product Name Confidence: Class 1
Synonyms trans-2-enoyl-CoA reductase
Evidence for Translation
Charge (pH 7) -12.87
Kyte-Doolittle Hydrophobicity Value -0.198
Molecular Weight (kDa) 43.5
Isoelectric Point (pI) 4.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 73 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002631 (408 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_25900
Search term: fabV

Human Homologs

References

Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase.
Zhu L, Lin J, Ma J, Cronan JE, Wang H
Antimicrob Agents Chemother 2010 Feb;54(2):689-98
PubMed ID: 19933806
Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa.
Huang YH, Lin JS, Ma JC, Wang HH
Front Microbiol 2016;7:1903
PubMed ID: 27965638