Pseudomonas aeruginosa UCBPP-PA14, PA14_69450 (hemC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_69450
Name
hemC
Replicon chromosome
Genomic location 6193708 - 6194649 (- strand)

Cross-References

RefSeq YP_793733.1
GI 116053408
EC Number 2.5.1.61
Entrez 4384482
INSDC ABJ14644.1
NCBI Locus Tag PA14_69450
UniParc UPI000045D557
UniProtKB Acc Q02EA3
UniProtKB ID HEM3_PSEAB
UniRef100 UniRef100_Q02EA3
UniRef50 UniRef50_Q4K3X3
UniRef90 UniRef90_A6VE37

Product

Feature Type CDS
Coding Frame 1
Product Name
porphobilinogen deaminase
Synonyms
Evidence for Translation
Charge (pH 7) -6.67
Kyte-Doolittle Hydrophobicity Value -0.085
Molecular Weight (kDa) 33.6
Isoelectric Point (pI) 5.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004841 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_69450
Search term: hemC

Human Homologs

Ensembl 110, assembly GRCh38.p14
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value: 9.1e-60
Percent Identity: 41.9
Ensembl 110, assembly GRCh38.p14
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value: 9.1e-60
Percent Identity: 41.9
Ensembl 110, assembly GRCh38.p14
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value: 9.1e-60
Percent Identity: 41.9
Ensembl 110, assembly GRCh38.p14
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value: 9.1e-60
Percent Identity: 41.9

References

No references are associated with this feature.