Pseudomonas aeruginosa UCBPP-PA14, PA14_70390 (crc)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_70390
Name	crc
Replicon	chromosome
Genomic location	6275040 - 6275819 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq	YP_793806.1
GI	116053479
Entrez	4385095
INSDC	ABJ14715.1
NCBI Locus Tag	PA14_70390
UniParc	UPI00000D4294
UniProtKB Acc	Q02E30
UniProtKB ID	Q02E30_PSEAB
UniRef100	UniRef100_W0Z3D9
UniRef50	UniRef50_Q49P76
UniRef90	UniRef90_A6VED9

Product

Feature Type	CDS
Coding Frame	1
Product Name	catabolite repression control protein
Synonyms
Evidence for Translation
Charge (pH 7)	-4.40
Kyte-Doolittle Hydrophobicity Value	-0.431
Molecular Weight (kDa)	29.8
Isoelectric Point (pI)	5.17

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6O1K	RNA BINDING PROTEIN/RNA/Hydrolase	02/20/19	Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE 2:2:2 complex (core complex)	Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	3.13	ELECTRON MICROSCOPY	100.0
6O1M	RNA BINDING PROTEIN/RNA/HYDROLASE	02/20/19	Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE 2:4:2 complex	Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT	3.15	ELECTRON MICROSCOPY	100.0
6O1L	RNA BINDING PROTEIN/RNA/HYDROLASE	02/20/19	Architectural principles for Hfq/Crc-mediated regulation of gene expression Hfq-Crc-amiE 2:3:2 complex	Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT	3.37	ELECTRON MICROSCOPY	100.0
8BVM	RNA BINDING PROTEIN	12/04/22	Cryo-EM structure of Hfq-Crc-rbsB translation repression complex	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	3.8	ELECTRON MICROSCOPY	100.0
4F1R	TRANSCRIPTION REGULATOR	05/07/12	Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginos	Pseudomonas aeruginosa	2.201	X-RAY DIFFRACTION	100.0
4JG3	UNKNOWN FUNCTION	02/28/13	Crystal structure of catabolite repression control protein (crc) from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	100.0
8BVH	RNA BINDING PROTEIN	12/03/22	Cryo-EM structure of the Hfq-Crc-amiE translation repression assembly.	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	3.6	ELECTRON MICROSCOPY	100.0
8BVJ	RNA BINDING PROTEIN	12/04/22	Hfq-Crc-estA translation repression complex	Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT	4.5	ELECTRON MICROSCOPY	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 492 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004901 (538 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_70390 Search term: crc Search term: catabolite repression control protein

Human Homologs

References