Pseudomonas aeruginosa PAO1, PA2703 (tsi2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2703
Name
tsi2
Replicon chromosome
Genomic location 3057376 - 3057609 (+ strand)

Cross-References

RefSeq NP_251393.1
GI 15597899
Affymetrix PA2703_at
Entrez 880324
GenBank AAG06091.1
INSDC AAG06091.1
NCBI Locus Tag PA2703
protein_id(GenBank) gb|AAG06091.1|AE004698_7|gnl|PseudoCAP|PA2703
TIGR NTL03PA02703
UniParc UPI00000C57BB
UniProtKB Acc Q9I0D9
UniProtKB ID Q9I0D9_PSEAE
UniRef100 UniRef100_Q9I0D9
UniRef50 UniRef50_Q9I0D9
UniRef90 UniRef90_Q9I0D9

Product

Feature Type CDS
Coding Frame 1
Product Name
Tsi2
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -8.05
Kyte-Doolittle Hydrophobicity Value -0.427
Molecular Weight (kDa) 8.5
Isoelectric Point (pI) 3.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4C18 TOXIN 08/10/13 The structure of the Tsi2 dimer with a disulfide bond PSEUDOMONAS AERUGINOSA 1.49 X-RAY DIFFRACTION 100.0
5AKO UNKNOWN FUNCTION 03/04/15 The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 100.0
3VPV TOXIN INHIBITOR 03/13/12 Crystal Structure of Pseudomonas aeruginosa Tsi2 Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 100.0
3STQ TOXIN 07/11/11 Hypothetical protein PA2703 Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa 2.284 X-RAY DIFFRACTION 100.0
3RQ9 TSE2-BINDING PROTEIN 04/27/11 Structure of Tsi2, a Tse2-immunity protein from Pseudomonas aeruginosa Pseudomonas aeruginosa 1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002861 (298 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2703
Search term: tsi2
Search term: Tsi2

Human Homologs

References

A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.
Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD
Cell Host Microbe 2010 Jan 21;7(1):25-37
PubMed ID: 20114026