Pseudomonas aeruginosa PAO1, PA2810 (copS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2810
Name
copS
Synonym: copS
Replicon chromosome
Genomic location 3163382 - 3164713 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentMutation leads to hypersensitivity to copper-mediated toxicity.

Cross-References

RefSeq NP_251500.1
GI 15598006
Affymetrix PA2810_at
Entrez 880411
GenBank AAG06198.1
INSDC AAG06198.1
NCBI Locus Tag PA2810
protein_id(GenBank) gb|AAG06198.1|AE004708_4|gnl|PseudoCAP|PA2810
TIGR NTL03PA02810
UniParc UPI00000C581C
UniProtKB Acc Q9I033
UniProtKB ID Q9I033_PSEAE
UniRef100 UniRef100_Q9I033
UniRef50 UniRef50_Q4KFA0
UniRef90 UniRef90_Q9I033

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor, CopS
Product Name Confidence: Class 1
Synonyms two-component sensor, CopS
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.82
Kyte-Doolittle Hydrophobicity Value -0.179
Molecular Weight (kDa) 49.2
Isoelectric Point (pI) 7.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001355 (1379 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2810
Search term: copS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
A two-component regulatory system required for copper-inducible expression of the copper resistance operon of Pseudomonas syringae.
Mills SD, Jasalavich CA, Cooksey DA
J Bacteriol 1993 Mar;175(6):1656-64
PubMed ID: 8449873