Pseudomonas aeruginosa PAO1, PA2850 (ohr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2850
Name
ohr
Replicon chromosome
Genomic location 3203998 - 3204426 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251540.1
GI 15598046
Affymetrix PA2850_ohr_at
DNASU PaCD00007241
Entrez 882604
GenBank AAG06238.1
INSDC AAG06238.1
NCBI Locus Tag PA2850
protein_id(GenBank) gb|AAG06238.1|AE004711_10|gnl|PseudoCAP|PA2850
TIGR NTL03PA02850
UniParc UPI00000C5842
UniProtKB Acc Q9HZZ3
UniProtKB ID Q9HZZ3_PSEAE
UniRef100 UniRef100_W0YU03
UniRef50 UniRef50_M7A8U3
UniRef90 UniRef90_Q02P13

Product

Feature Type CDS
Coding Frame 1
Product Name
organic hydroperoxide resistance protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.40
Kyte-Doolittle Hydrophobicity Value 0.056
Molecular Weight (kDa) 14.5
Isoelectric Point (pI) 7.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1N2F OXIDOREDUCTASE 10/22/02 CRYSTAL STRUCTURE OF P. AERUGINOSA OHR Pseudomonas aeruginosa 2.01 X-RAY DIFFRACTION 97.9

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
1,4-Dithiothreitol DB04447 DrugBank 5.1.4 Q9HZZ3 Organic hydroperoxide resistance protein 100.0 142 2.0e-73

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 226 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002718 (505 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2850
Search term: ohr

Human Homologs

References

Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli.
Mongkolsuk S, Praituan W, Loprasert S, Fuangthong M, Chamnongpol S
J Bacteriol 1998 May;180(10):2636-43
PubMed ID: 9573147