Pseudomonas aeruginosa PAO1, PA2866 (mttC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2866
Name
mttC
Replicon chromosome
Genomic location 3218666 - 3219469 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251556.1
GI 15598062
Affymetrix PA2866_mttC_at
DNASU PaCD00007251
Entrez 882594
GenBank AAG06254.1
INSDC AAG06254.1
NCBI Locus Tag PA2866
protein_id(GenBank) gb|AAG06254.1|AE004713_3|gnl|PseudoCAP|PA2866
TIGR NTL03PA02866
UniParc UPI00000C584E
UniProtKB Acc Q9HZY0
UniProtKB ID Q9HZY0_PSEAE
UniRef100 UniRef100_Q9HZY0
UniRef50 UniRef50_S5EE06
UniRef90 UniRef90_Q9HZY0

Product

Feature Type CDS
Coding Frame 1
Product Name
secretion protein MttC
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.47
Kyte-Doolittle Hydrophobicity Value -0.219
Molecular Weight (kDa) 29.5
Isoelectric Point (pI) 6.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002703 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2866
Search term: mttC

Human Homologs

Ensembl 110, assembly GRCh38.p14
TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988]
E-value: 2.5e-18
Percent Identity: 32.4
Ensembl 110, assembly GRCh38.p14
TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988]
E-value: 2.5e-18
Percent Identity: 32.4

References

A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins.
Weiner JH, Bilous PT, Shaw GM, Lubitz SP, Frost L, Thomas GH, Cole JA, Turner RJ
Cell 1998 Apr 3;93(1):93-101
PubMed ID: 9546395