Pseudomonas aeruginosa PAO1, PA2975 (rluC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2975
Name
rluC
Synonym: yceC
Replicon chromosome
Genomic location 3331348 - 3332304 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251665.1
GI 15598171
Affymetrix PA2975_rluC_at
DNASU PaCD00007300
Entrez 880474
GenBank AAG06363.1
INSDC AAG06363.1
NCBI Locus Tag PA2975
protein_id(GenBank) gb|AAG06363.1|AE004723_7|gnl|PseudoCAP|PA2975
TIGR NTL03PA02975
UniParc UPI00000C58AF
UniProtKB Acc Q9HZM9
UniProtKB ID RLUC_PSEAE
UniRef100 UniRef100_Q9HZM9
UniRef50 UniRef50_Q9HZM9
UniRef90 UniRef90_Q9HZM9

Product

Feature Type CDS
Coding Frame 1
Product Name
ribosomal large subunit pseudouridine synthase C
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 14.66
Kyte-Doolittle Hydrophobicity Value -0.405
Molecular Weight (kDa) 35.6
Isoelectric Point (pI) 10.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 590 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002607 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2975
Search term: rluC

Human Homologs

Ensembl 110, assembly GRCh38.p14
RNA pseudouridine synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180]
E-value: 7.2e-20
Percent Identity: 28.6

References

The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA.
Conrad J, Sun D, Englund N, Ofengand J
J Biol Chem 1998 Jul 17;273(29):18562-6
PubMed ID: 9660827