Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3204
|
Name |
cpxR
|
Replicon | chromosome |
Genomic location | 3594581 - 3595258 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
RefSeq | NP_251894.1 |
GI | 15598400 |
Affymetrix | PA3204_at |
Entrez | 882544 |
GenBank | AAG06592.1 |
INSDC | AAG06592.1 |
NCBI Locus Tag | PA3204 |
protein_id(GenBank) | gb|AAG06592.1|AE004744_7|gnl|PseudoCAP|PA3204 |
TIGR | NTL03PA03204 |
UniParc | UPI00000C594A |
UniProtKB Acc | Q9HZ36 |
UniProtKB ID | Q9HZ36_PSEAE |
UniRef100 | UniRef100_W0YUZ4 |
UniRef50 | UniRef50_Q4KGB4 |
UniRef90 | UniRef90_M4WZL9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
two-component response regulator CpxR
|
Synonyms |
probable two-component response regulator |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -3.62 |
Kyte-Doolittle Hydrophobicity Value | -0.280 |
Molecular Weight (kDa) | 24.8 |
Isoelectric Point (pI) | 5.96 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
Pseudomonas aeruginosa CpxR | CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. [PMID:27736975] | ARO:3004054 | protein homolog model | Perfect | 444.1 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002411 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3204
Search term: cpxR
Search term: two-component response regulator CpxR
|
The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component.
Weber RF, Silverman PM
J Mol Biol 1988 Sep 20;203(2):467-78
PubMed ID: 3058985
|
CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa.
Tian ZX, Yi XX, Cho A, O'Gara F, Wang YP
PLoS Pathog 2016 Oct;12(10):e1005932
PubMed ID: 27736975
|