Pseudomonas aeruginosa PAO1, PA3247

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA3247
Name
Replicon	chromosome
Genomic location	3633592 - 3634881 (+ strand)
Transposon Mutants	4 transposon mutants in PAO1
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	NP_251937.1
GI	15598443
Affymetrix	PA3247_at
Entrez	882410
GenBank	AAG06635.1
INSDC	AAG06635.1
NCBI Locus Tag	PA3247
protein_id(GenBank)	gb|AAG06635.1|AE004747_8|gnl|PseudoCAP|PA3247
TIGR	NTL03PA03247
UniParc	UPI0000125C47
UniProtKB Acc	Q9HYZ3
UniProtKB ID	APEB_PSEAE
UniRef100	UniRef100_B7V7X2
UniRef50	UniRef50_Q87YC5
UniRef90	UniRef90_A6V2H4

Product

Feature Type	CDS
Coding Frame	1
Product Name	hypothetical protein Product Name Confidence: Class 4
Synonyms
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-9.38
Kyte-Doolittle Hydrophobicity Value	-0.140
Molecular Weight (kDa)	46.7
Isoelectric Point (pI)	5.96

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
2IJZ	HYDROLASE	10/02/06	Crystal structure of aminopeptidase	Pseudomonas aeruginosa	3	X-RAY DIFFRACTION	99.8
4NJQ	HYDROLASE	11/11/13	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.702	X-RAY DIFFRACTION	100.0
4OID	HYDROLASE	01/19/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa PAO1	2.3	X-RAY DIFFRACTION	99.8
3WT4	HYDROLASE	04/07/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	100.0
4NJR	HYDROLASE	11/11/13	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	100.0
4OIW	HYDROLASE	01/20/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.44	X-RAY DIFFRACTION	99.8

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 157 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002361 (536 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA3247

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000431076 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 3.0e-90 Percent Identity: 41.4
Ensembl 110, assembly GRCh38.p14	ENSP00000273075 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 3.0e-90 Percent Identity: 41.4
Ensembl 110, assembly GRCh38.p14	ENSP00000429468 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 3.0e-90 Percent Identity: 41.4

References