Pseudomonas aeruginosa PAO1, PA4005

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4005
Name
Synonym: ybeB
Replicon chromosome
Genomic location 4485824 - 4486180 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252694.1
GI 15599200
Affymetrix PA4005_at
DNASU PaCD00007747
Entrez 878974
GenBank AAG07392.1
INSDC AAG07392.1
NCBI Locus Tag PA4005
protein_id(GenBank) gb|AAG07392.1|AE004817_16|gnl|PseudoCAP|PA4005
TIGR NTL03PA04005
UniParc UPI00000C5BBB
UniProtKB Acc Q9HX22
UniProtKB ID Q9HX22_PSEAE
UniRef100 UniRef100_Q02SH2
UniRef50 UniRef50_Q02SH2
UniRef90 UniRef90_Q02SH2

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Detected by iTRAQ (PMID:21863142).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.56
Kyte-Doolittle Hydrophobicity Value -0.310
Molecular Weight (kDa) 13.1
Isoelectric Point (pI) 4.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 565 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001678 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4005

Human Homologs

Ensembl 110, assembly GRCh38.p14
mitochondrial assembly of ribosomal large subunit 1 [Source:HGNC Symbol;Acc:HGNC:21721]
E-value: 1.1e-10
Percent Identity: 32.8

References

Nucleotide sequence of the pbpA gene and characteristics of the deduced amino acid sequence of penicillin-binding protein 2 of Escherichia coli K12.
Asoh S, Matsuzawa H, Ishino F, Strominger JL, Matsuhashi M, Ohta T
Eur J Biochem 1986 Oct 15;160(2):231-8
PubMed ID: 3533535
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142