Pseudomonas aeruginosa PAO1, PA4612

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4612
Name
Synonym: ankB
Replicon chromosome
Genomic location 5169580 - 5170131 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253302.1
GI 15599808
Affymetrix PA4612_at
DNASU PaCD00007998
Entrez 881115
GenBank AAG08000.1
INSDC AAG08000.1
NCBI Locus Tag PA4612
protein_id(GenBank) gb|AAG08000.1|AE004875_6|gnl|PseudoCAP|PA4612
TIGR NTL03PA04613
UniParc UPI00000C5D8A
UniProtKB Acc G3XD34
UniProtKB ID G3XD34_PSEAE
UniRef100 UniRef100_G3XD34
UniRef50 UniRef50_Q48GP8
UniRef90 UniRef90_Q02G65

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.34
Kyte-Doolittle Hydrophobicity Value -0.048
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 5.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Periplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 244 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004267 (436 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4612

Human Homologs

References

AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide.
Howell ML, Alsabbagh E, Ma JF, Ochsner UA, Klotz MG, Beveridge TJ, Blumenthal KM, Niederhoffer EC, Morris RE, Needham D, Dean GE, Wani MA, Hassett DJ
J Bacteriol 2000 Aug;182(16):4545-56
PubMed ID: 10913088
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295