Pseudomonas aeruginosa PAO1, PA4964 (parC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4964
Name
parC
Replicon chromosome
Genomic location 5572222 - 5574486 (- strand)

Cross-References

RefSeq NP_253651.1
GI 15600157
Affymetrix PA4964_parC_at
Entrez 879741
GenBank AAG08349.1
INSDC AAG08349.1
NCBI Locus Tag PA4964
protein_id(GenBank) gb|AAG08349.1|AE004909_5|gnl|PseudoCAP|PA4964
TIGR NTL03PA04965
UniParc UPI00000C5E9B
UniProtKB Acc Q9HUK1
UniProtKB ID PARC_PSEAE
UniRef100 UniRef100_Q9HUK1
UniRef50 UniRef50_Q9HUK1
UniRef90 UniRef90_Q9HUK1

Product

Feature Type CDS
Coding Frame 1
Product Name
topoisomerase IV subunit A
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.48
Kyte-Doolittle Hydrophobicity Value -0.305
Molecular Weight (kDa) 83.4
Isoelectric Point (pI) 5.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 630 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004579 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4964
Search term: parC

Human Homologs

References

Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions.
Peng H, Marians KJ
J Biol Chem 1993 Nov 15;268(32):24481-90
PubMed ID: 8227000
Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV.
Akasaka T, Onodera Y, Tanaka M, Sato K
Antimicrob Agents Chemother 1999 Mar;43(3):530-6
PubMed ID: 10049263