Pseudomonas aeruginosa PAO1, PA5067 (hisE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5067
Name
hisE
Replicon chromosome
Genomic location 5706191 - 5706526 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253754.1
GI 15600260
Affymetrix PA5067_hisE_at
DNASU PaCD00008179
Entrez 878486
GenBank AAG08452.1
INSDC AAG08452.1
NCBI Locus Tag PA5067
protein_id(GenBank) gb|AAG08452.1|AE004920_2|gnl|PseudoCAP|PA5067
TIGR NTL03PA05068
UniParc UPI000012C785
UniProtKB Acc Q9HUB6
UniProtKB ID HIS2_PSEAE
UniRef100 UniRef100_B7V3G0
UniRef50 UniRef50_Q87UY8
UniRef90 UniRef90_C1DHS6

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosyl-ATP pyrophosphohydrolase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.08
Kyte-Doolittle Hydrophobicity Value -0.208
Molecular Weight (kDa) 12.0
Isoelectric Point (pI) 4.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 454 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004668 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5067
Search term: hisE

Human Homologs

References

Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region.
Chiariotti L, Alifano P, Carlomagno MS, Bruni CB
Mol Gen Genet 1986 Jun;203(3):382-8
PubMed ID: 3018428