Pseudomonas aeruginosa PAO1, PA0750 (ung)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0750
Name
ung
Replicon chromosome
Genomic location 818003 - 818698 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249441.1
GI 15595947
Affymetrix PA0750_ung_at
Entrez 881872
GenBank AAG04139.1
INSDC AAG04139.1
NCBI Locus Tag PA0750
protein_id(GenBank) gb|AAG04139.1|AE004510_3|gnl|PseudoCAP|PA0750
TIGR NTL03PA00751
UniParc UPI0000137C81
UniProtKB Acc Q9I5H9
UniProtKB ID UNG_PSEAE
UniRef100 UniRef100_A6VAM7
UniRef50 UniRef50_Q8A5V6
UniRef90 UniRef90_A6VAM7

Product

Feature Type CDS
Coding Frame 1
Product Name
uracil-DNA glycosylase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.62
Kyte-Doolittle Hydrophobicity Value -0.464
Molecular Weight (kDa) 26.0
Isoelectric Point (pI) 8.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 353 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000724 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0750
Search term: ung

Human Homologs

Ensembl 97, assembly GRCh38.p12
uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572]
E-value: 6.6e-64
Percent Identity: 54.0

Human Homologs

Ensembl 97, assembly GRCh38.p12
uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572]
E-value: 6.6e-64
Percent Identity: 54.0

References

Sequence analysis, expression, and conservation of Escherichia coli uracil DNA glycosylase and its gene (ung).
Varshney U, Hutcheon T, van de Sande JH
J Biol Chem 1988 Jun 5;263(16):7776-84
PubMed ID: 2836397
X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG.
Ravishankar R, Bidya Sagar M, Roy S, Purnapatre K, Handa P, Varshney U, Vijayan M
Nucleic Acids Res. 1998 Nov;26(21):4880-7
PubMed ID: 9776748