Pseudomonas aeruginosa PAO1, PA0765 (mucC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0765
Name
mucC
Replicon chromosome
Genomic location 833454 - 833909 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_249456.1
GI 15595962
Affymetrix PA0765_mucC_at
DNASU PaCD00006351
Entrez 877954
GenBank AAG04154.1
INSDC AAG04154.1
NCBI Locus Tag PA0765
protein_id(GenBank) gb|AAG04154.1|AE004511_7|gnl|PseudoCAP|PA0765
TIGR NTL03PA00766
UniParc UPI00000D4233
UniProtKB Acc G3XCY1
UniProtKB ID G3XCY1_PSEAE
UniRef100 UniRef100_W0YM94
UniRef50 UniRef50_A6VAL1
UniRef90 UniRef90_A6VAL1

Product

Feature Type CDS
Coding Frame 1
Product Name
positive regulator for alginate biosynthesis MucC
Product Name Confidence: Class 1
Synonyms AlgM
Evidence for Translation
Charge (pH 7) 3.62
Kyte-Doolittle Hydrophobicity Value 0.515
Molecular Weight (kDa) 15.9
Isoelectric Point (pI) 8.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0091
Category Alginate regulation
Evidence
Host Organism
Notes
Reference
Source 2
Database Victors : 4211
Category Alginate regulation
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes
Infection model Rat agar bead model of chronic lung infection
Reference 14641575

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 84 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000739 (345 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0765
Search term: mucC

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity.
Boucher JC, Schurr MJ, Yu H, Rowen DW, Deretic V
Microbiology (Reading, Engl.) 1997 Nov;143 ( Pt 11)
PubMed ID: 9387225