Pseudomonas aeruginosa PAO1, PA0873 (phhR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0873
Name
phhR
Synonym: tyrR
Replicon chromosome
Genomic location 953691 - 955250 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249564.1
GI 15596070
Affymetrix PA0873_phhR_at
Entrez 878408
GenBank AAG04262.1
INSDC AAG04262.1
NCBI Locus Tag PA0873
protein_id(GenBank) gb|AAG04262.1|AE004522_4|gnl|PseudoCAP|PA0873
TIGR NTL03PA00874
UniParc UPI00000C519B
UniProtKB Acc Q9I572
UniProtKB ID Q9I572_PSEAE
UniRef100 UniRef100_Q9I572
UniRef50 UniRef50_Q9I572
UniRef90 UniRef90_Q9I572

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator PhhR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.91
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 56.9
Isoelectric Point (pI) 6.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 456 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000840 (521 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0873
Search term: phhR

Human Homologs

References

PhhR, a divergently transcribed activator of the phenylalanine hydroxylase gene cluster of Pseudomonas aeruginosa.
Song J, Jensen RA
Mol Microbiol 1996 Nov;22(3):497-507
PubMed ID: 8939433