Pseudomonas aeruginosa PAO1, PA1006

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1006
Name
Synonym: YhhP/TusA homolog
Synonym: yrkI
Replicon chromosome
Genomic location 1090606 - 1090857 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249697.1
GI 15596203
Affymetrix PA1006_at
DNASU PaCD00006464
Entrez 879448
GenBank AAG04395.1
INSDC AAG04395.1
NCBI Locus Tag PA1006
protein_id(GenBank) gb|AAG04395.1|AE004533_6|gnl|PseudoCAP|PA1006
TIGR NTL03PA01007
UniParc UPI00000C51FD
UniProtKB Acc Q9I4W7
UniProtKB ID Q9I4W7_PSEAE
UniRef100 UniRef100_W0YNA1
UniRef50 UniRef50_V6J1K7
UniRef90 UniRef90_A6V9K8

Product

Feature Type CDS
Coding Frame 1
Product Name
Protein PA1006
Product Name Confidence: Class 1
Synonyms conserved hypothetical protein
Evidence for Translation
Charge (pH 7) -0.84
Kyte-Doolittle Hydrophobicity Value -0.271
Molecular Weight (kDa) 9.1
Isoelectric Point (pI) 5.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes PA1006 mutant is attenuated for virulence in rat agar bead model of chronic lung infection
Infection model Rat agar bead model of chronic lung infection
Reference 23409004
Source 2
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes PA1006 mutant is attenuated for virulence in burned mouse model
Infection model Burned mouse model
Reference 23409004

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 278 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000969 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1006
Search term: Protein PA1006

References

Pseudomonas aeruginosa PA1006, which plays a role in molybdenum homeostasis, is required for nitrate utilization, biofilm formation, and virulence.
Filiatrault MJ, Tombline G, Wagner VE, Van Alst N, Rumbaugh K, Sokol P, Schwingel J, Iglewski BH
PLoS ONE 2013 ;8(2):e55594
PubMed ID: 23409004
Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis.
Tombline G, Schwingel JM, Lapek JD, Friedman AE, Darrah T, Maguire M, Van Alst NE, Filiatrault MJ, Iglewski BH
PLoS ONE 2013 ;8(2):e55593
PubMed ID: 23409003