Pseudomonas aeruginosa PAO1, PA1098 (fleS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1098
Name
fleS
Replicon chromosome
Genomic location 1189172 - 1190380 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249789.1
GI 15596295
Affymetrix PA1098_fleS_at
Entrez 878201
GenBank AAG04487.1
INSDC AAG04487.1
NCBI Locus Tag PA1098
protein_id(GenBank) gb|AAG04487.1|AE004540_7|gnl|PseudoCAP|PA1098
TIGR NTL03PA01099
UniParc UPI00000C5248
UniProtKB Acc Q9I4N4
UniProtKB ID Q9I4N4_PSEAE
UniRef100 UniRef100_Q9I4N4
UniRef50 UniRef50_Q9I4N4
UniRef90 UniRef90_Q9I4N4

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.73
Kyte-Doolittle Hydrophobicity Value -0.129
Molecular Weight (kDa) 43.9
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001059 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1098
Search term: fleS

References

Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin.
Ritchings BW, Almira EC, Lory S, Ramphal R
Infect. Immun. 1995 Dec;63(12):4868-76
PubMed ID: 7591148
A transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner.
Arora SK, Ritchings BW, Almira EC, Lory S, Ramphal R
J. Bacteriol. 1997 Sep;179(17):5574-81
PubMed ID: 9287015