Pseudomonas aeruginosa PAO1, PA1224

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1224
Name
Replicon chromosome
Genomic location 1327024 - 1327803 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_249915.1
GI 15596421
Affymetrix PA1224_at
DNASU PaCD00006568
Entrez 879344
GenBank AAG04613.1
INSDC AAG04613.1
NCBI Locus Tag PA1224
protein_id(GenBank) gb|AAG04613.1|AE004552_3|gnl|PseudoCAP|PA1224
TIGR NTL03PA01225
UniParc UPI00000C52B9
UniProtKB Acc Q9I4B4
UniProtKB ID Q9I4B4_PSEAE
UniRef100 UniRef100_K1CUR8
UniRef50 UniRef50_T2LB62
UniRef90 UniRef90_A0A081HQT6

Product

Feature Type CDS
Coding Frame 1
Product Name
probable NAD(P)H dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -4.87
Kyte-Doolittle Hydrophobicity Value -0.208
Molecular Weight (kDa) 28.9
Isoelectric Point (pI) 6.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 274 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000820 (1495 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1224

Human Homologs

Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 2.1e-38
Percent Identity: 40.9
Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 2.1e-38
Percent Identity: 40.9
Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 2.1e-38
Percent Identity: 40.9

References

Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis.
Forrest GL, Qian J, Ma JX, Kaplan WD, Akman S, Doroshow J, Chen SA
Biochem Biophys Res Commun 1990 Jun 29;169(3):1087-93
PubMed ID: 2141979