Pseudomonas aeruginosa PAO1, PA1901 (phzC2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1901
Name
phzC2
Replicon chromosome
Genomic location 2071721 - 2072938 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250592.1
GI 15597098
Affymetrix PA1901_s_at
Entrez 882061
GenBank AAG05290.1
NCBI Locus Tag PA1901
protein_id(GenBank) gb|AAG05290.1|AE004616_4|gnl|PseudoCAP|PA1901
TIGR NTL03PA01902
UniProtKB Acc Q7DC82
UniProtKB ID Q7DC82_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
phenazine biosynthesis protein PhzC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.90
Kyte-Doolittle Hydrophobicity Value -0.259
Molecular Weight (kDa) 44.3
Isoelectric Point (pI) 7.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6BMC TRANSFERASE 11/14/17 The structure of a dimeric type II DAH7PS associated with pyocyanin biosynthesis in Pseudomonas aeruginosa Pseudomonas aeruginosa 2.7 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB
Category Phenazine biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 167 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001495 (461 members)
Putative Inparalogs 1 predicted inparalogs
phenazine biosynthesis protein PhzC (PA4212) 100.0% identity

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1901
Search term: phzC2

Human Homologs

References

Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
J Bacteriol 2001 Nov;183(21):6454-65
PubMed ID: 11591691
Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.
Pierson LS 3rd, Gaffney T, Lam S, Gong F
FEMS Microbiol Lett 1995 Dec 15;134(2-3):299-307
PubMed ID: 8586283