Pseudomonas aeruginosa PAO1, PA3097 (xcpX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3097
Name
xcpX
Replicon chromosome
Genomic location 3477627 - 3478628 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251787.1
GI 15598293
Affymetrix PA3097_xcpX_at
DNASU PaCD00007362
Entrez 882779
GenBank AAG06485.1
INSDC AAG06485.1
NCBI Locus Tag PA3097
protein_id(GenBank) gb|AAG06485.1|AE004734_3|gnl|PseudoCAP|PA3097
TIGR NTL03PA03097
UniParc UPI000012BC62
UniProtKB Acc Q00518
UniProtKB ID GSPK_PSEAE
UniRef100 UniRef100_Q00518
UniRef50 UniRef50_Q00518
UniRef90 UniRef90_Q00518

Product

Feature Type CDS
Coding Frame 1
Product Name
general secretion pathway protein K
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.94
Kyte-Doolittle Hydrophobicity Value -0.431
Molecular Weight (kDa) 37.0
Isoelectric Point (pI) 9.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5VTM TRANSPORT PROTEIN 05/17/17 The crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.041 X-RAY DIFFRACTION 100.0
6UTU PROTEIN TRANSPORT 10/30/19 Crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa in the P3 space group Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.85 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 107 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000661 (723 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3097
Search term: xcpX

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase.
Bally M, Filloux A, Akrim M, Ball G, Lazdunski A, Tommassen J
Mol Microbiol 1992 May;6(9):1121-31
PubMed ID: 1588814