Pseudomonas aeruginosa PA7, PSPA7_0020 (def)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_0020
Name
def
Replicon chromosome
Genomic location 20944 - 21450 (- strand)

Cross-References

RefSeq YP_001345416.1
GI 152988653
EC Number 3.5.1.88
Entrez 5357812
NCBI Locus Tag PSPA7_0020

Product

Feature Type CDS
Coding Frame 1
Product Name
peptide deformylase
Synonyms
Evidence for Translation
Charge (pH 7) -7.13
Kyte-Doolittle Hydrophobicity Value -0.447
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 4.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1N5N HYDROLASE 11/06/02 Crystal Structure of Peptide Deformylase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 98.8
1LRY HYDROLASE 05/16/02 Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin Pseudomonas aeruginosa 2.6 X-RAY DIFFRACTION 98.2
1S17 HYDROLASE 01/05/04 Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 98.8
1IX1 HYDROLASE 06/07/02 Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin Pseudomonas aeruginosa 1.85 X-RAY DIFFRACTION 98.2

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-(2-Acetamido)Iminodiacetic Acid DB02810 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 98.2 168 4.7e-90
2-(3,4-Dihydro-3-Oxo-2h-Benzo[B][1,4]Thiazin-2-Yl)-N-Hydroxyacetamide DB02036 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 98.2 168 4.7e-90
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide DB04310 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 98.2 168 4.7e-90

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 587 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000019 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_0020
Search term: def

Human Homologs

Ensembl 110, assembly GRCh38.p14
peptide deformylase, mitochondrial [Source:HGNC Symbol;Acc:HGNC:30012]
E-value: 4.3e-16
Percent Identity: 32.7

References

No references are associated with this feature.