Pseudomonas entomophila L48, PSEEN1165 (pcaF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas entomophila L48
GCF_000026105.1|latest
Locus Tag
PSEEN1165
Name
pcaF
Replicon chromosome
Genomic location 1214675 - 1215877 (+ strand)

Cross-References

RefSeq YP_606872.1
GI 104780374
EC Number 2.3.1.9
Entrez 4086120

Product

Feature Type CDS
Coding Frame 1
Product Name
beta-ketoadipyl CoA thiolase
Synonyms
Evidence for Translation
Charge (pH 7) -2.90
Kyte-Doolittle Hydrophobicity Value 0.076
Molecular Weight (kDa) 41707.4
Isoelectric Point (pI) 6.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6PCD TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase mutant (C90S-H356A) in complex Octanoyl coenzyme A Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.37 X-RAY DIFFRACTION 95.0
6PCA TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.81 X-RAY DIFFRACTION 95.5
6PCB TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.61 X-RAY DIFFRACTION 95.2
6PCC TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex hexanoyl coenzyme A Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.96 X-RAY DIFFRACTION 95.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 482 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000227 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSEEN1165
Search term: pcaF

Human Homologs

Ensembl 110, assembly GRCh38.p14
acetyl-CoA acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:83]
E-value: 6.6e-79
Percent Identity: 42.8

References

No references are associated with this feature.