Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0928
|
Name |
gacS
Synonym: lemA |
Replicon | chromosome |
Genomic location | 1012975 - 1015752 (- strand) |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_249619.1 |
GI | 15596125 |
Affymetrix | PA0928_at |
Entrez | 880882 |
GenBank | AAG04317.1 |
INSDC | AAG04317.1 |
NCBI Locus Tag | PA0928 |
protein_id(GenBank) | gb|AAG04317.1|AE004527_4|gnl|PseudoCAP|PA0928 |
TIGR | NTL03PA00929 |
UniParc | UPI00000D428B |
UniProtKB Acc | G3XD98 |
UniProtKB ID | G3XD98_PSEAE |
UniRef100 | UniRef100_G3XD98 |
UniRef50 | UniRef50_P48027 |
UniRef90 | UniRef90_G3XD98 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
sensor/response regulator hybrid
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -35.52 |
Kyte-Doolittle Hydrophobicity Value | -0.160 |
Molecular Weight (kDa) | 101.0 |
Isoelectric Point (pI) | 4.71 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7QZ2 | SIGNALING PROTEIN | 01/30/22 | Crystal structure of GacS D1 domain in complex with BeF3- | Pseudomonas aeruginosa | 1.87 | X-RAY DIFFRACTION | 100.0 |
5O7J | SIGNALING PROTEIN | 06/09/17 | Structural insights into the periplasmic sensor domain of the GacS histidine kinase controlling biofilm formation in Pseudomonas aeruginosa | Pseudomonas aeruginosa | NOT | SOLUTION NMR | 100.0 |
7QZO | SIGNALING PROTEIN | 01/31/22 | Crystal structure of GacS D1 domain | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 100.0 |
7Z8N | SIGNALING PROTEIN | 03/17/22 | GacS histidine kinase from Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 2.64 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | VFDB |
Category | GacS/GacA two-component system |
Evidence |
|
Host Organism | |
Notes | |
Reference |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 624 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000894 (527 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0928
Search term: gacS
Search term: sensor/response regulator hybrid
|
A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa.
Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S
Dev Cell 2004 Nov;7(5):745-54
PubMed ID: 15525535
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
A global regulator of secondary metabolite production in Pseudomonas fluorescens Pf-5.
Corbell N, Loper JE
J Bacteriol 1995 Nov;177(21):6230-6
PubMed ID: 7592389
|