Pseudomonas aeruginosa PAO1, PA3721 (nalC)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0034763	negative regulation of transmembrane transport	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	15387820	Reviewed by curator
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	22393435	Reviewed by curator
Molecular Function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	22393435	Reviewed by curator
Biological Process	GO:0032410	negative regulation of transporter activity	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	15387820	Reviewed by curator
Biological Process	GO:0032410	negative regulation of transporter activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	15387820	Reviewed by curator
Molecular Function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay	ECO:0000096 electrophoretic mobility shift assay evidence	22393435	Reviewed by curator
Molecular Function	GO:0003677	DNA binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PR00455	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Transcriptional regulators Other PAO1 genes in this class Antibiotic resistance and susceptibility Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01501	beta-Lactam resistance	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF14246	AefR-like transcriptional repressor, C-terminal domain	IPR039536	Transcriptional regulator TetR, C-terminal, Proteobacteria type	90	199	4.7E-15
Gene3D	G3DSA:1.10.357.10	Tetracycline Repressor, domain 2	-	-	7	204	2.6E-43
PANTHER	PTHR30055	HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR	-	-	3	187	4.7E-19
SUPERFAMILY	SSF46689	Homeodomain-like	IPR009057	Homeobox-like domain superfamily	7	81	9.48E-19
PRINTS	PR00455	TetR bacterial regulatory protein HTH signature	IPR001647	DNA-binding HTH domain, TetR-type	19	32	1.4E-7
Pfam	PF00440	Bacterial regulatory proteins, tetR family	IPR001647	DNA-binding HTH domain, TetR-type	20	65	3.5E-14
PRINTS	PR00455	TetR bacterial regulatory protein HTH signature	IPR001647	DNA-binding HTH domain, TetR-type	40	63	1.4E-7

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.