Pseudomonas aeruginosa PAO1, PA4180

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0030976	thiamine pyrophosphate binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF02776	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0000287	magnesium ion binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00205	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF02775	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00650	Butanoate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	ILEUSYN-PWY	L-isoleucine biosynthesis I (from threonine)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00770	Pantothenate and CoA biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	BRANCHED-CHAIN-AA-SYN-PWY	superpathway of branched amino acid biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01210	2-Oxocarboxylic acid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00660	C5-Branched dibasic acid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00290	Valine, leucine and isoleucine biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
CDD	cd07035	TPP_PYR_POX_like	-	-	6	160	2.39637E-59
SUPERFAMILY	SSF52467	DHS-like NAD/FAD-binding domain	IPR029035	DHS-like NAD/FAD-binding domain superfamily	154	335	1.8E-38
Gene3D	G3DSA:3.40.50.970	-	-	-	348	539	2.7E-55
Gene3D	G3DSA:3.40.50.970	-	-	-	1	171	3.1E-54
Pfam	PF02776	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	IPR012001	Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain	3	169	1.8E-53
CDD	cd02010	TPP_ALS	-	-	359	535	3.78431E-113
Pfam	PF02775	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	IPR011766	Thiamine pyrophosphate enzyme, TPP-binding	379	525	1.1E-38
Gene3D	G3DSA:3.40.50.1220	-	-	-	181	345	2.7E-38
SUPERFAMILY	SSF52518	Thiamin diphosphate-binding fold (THDP-binding)	IPR029061	Thiamin diphosphate-binding fold	3	179	2.54E-48
Pfam	PF00205	Thiamine pyrophosphate enzyme, central domain	IPR012000	Thiamine pyrophosphate enzyme, central domain	189	319	2.3E-30
PANTHER	PTHR18968	THIAMINE PYROPHOSPHATE ENZYMES	IPR045229	Thiamine pyrophosphate enzyme	2	532	0.0
FunFam	G3DSA:3.40.50.970:FF:000007	Acetolactate synthase	-	-	1	179	4.7E-57
SUPERFAMILY	SSF52518	Thiamin diphosphate-binding fold (THDP-binding)	IPR029061	Thiamin diphosphate-binding fold	356	534	3.32E-58

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.