Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0424
|
Name |
mexR
|
Replicon | chromosome |
Genomic location | 471306 - 471749 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
RefSeq | NP_249115.1 |
GI | 15595621 |
Affymetrix | PA0424_mexR_at |
DNASU | PaCD00006181 |
Entrez | 877857 |
GenBank | AAG03813.1 |
INSDC | AAG03813.1 |
NCBI Locus Tag | PA0424 |
protein_id(GenBank) | gb|AAG03813.1|AE004479_8|gnl|PseudoCAP|PA0424 |
TIGR | NTL03PA00425 |
UniParc | UPI000012F023 |
UniProtKB Acc | P52003 |
UniProtKB ID | MEXR_PSEAE |
UniRef100 | UniRef100_P52003 |
UniRef50 | UniRef50_P52003 |
UniRef90 | UniRef90_P52003 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
multidrug resistance operon repressor MexR
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -3.65 |
Kyte-Doolittle Hydrophobicity Value | -0.355 |
Molecular Weight (kDa) | 17.0 |
Isoelectric Point (pI) | 5.92 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexR | MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. [PMID:14526032, PMID:12727072, PMID:20616806, PMID:18812515] | ARO:3000506 | protein overexpression model | Strict | 295.0 | 100.0 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
1LNW | TRANSCRIPTION REPRESSOR | 05/03/02 | CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 100.0 |
3MEX | Transcription, Transcription Regulation | 04/01/10 | Crystal structure of MexR in oxidized state | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.3 |
4ZZL | TRANSCRIPTION | 04/10/15 | MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression | PSEUDOMONAS AERUGINOSA | 2.19 | X-RAY DIFFRACTION | 99.3 |
3ECH | Transcription, Transcription regulation | 08/30/08 | The MarR-family repressor MexR in complex with its antirepressor ArmR | Pseudomonas aeruginosa | 1.802 | X-RAY DIFFRACTION | 98.6 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 211 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000415 (299 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0424
Search term: mexR
Search term: multidrug resistance operon repressor MexR
|
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.
Poole K, Tetro K, Zhao Q, Neshat S, Heinrichs DE, Bianco N
Antimicrob Agents Chemother 1996 Sep;40(9):2021-8
PubMed ID: 8878574
|