Pseudomonas aeruginosa PAO1, PA2518 (xylX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2518
Name
xylX
Replicon chromosome
Genomic location 2834687 - 2836054 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_251208.1
GI 15597714
Affymetrix PA2518_xylX_at
Entrez 882903
GenBank AAG05906.1
INSDC AAG05906.1
NCBI Locus Tag PA2518
protein_id(GenBank) gb|AAG05906.1|AE004678_12|gnl|PseudoCAP|PA2518
TIGR NTL03PA02518
UniParc UPI00000C5718
UniProtKB Acc Q9I0W4
UniProtKB ID Q9I0W4_PSEAE
UniRef100 UniRef100_Q9I0W4
UniRef50 UniRef50_Q51601
UniRef90 UniRef90_A6V4U4

Product

Feature Type CDS
Coding Frame 1
Product Name
toluate 1,2-dioxygenase alpha subunit
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -6.10
Kyte-Doolittle Hydrophobicity Value -0.560
Molecular Weight (kDa) 51.7
Isoelectric Point (pI) 6.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 193 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003046 (1308 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2518
Search term: xylX

Human Homologs

References

Genetic analysis of a relaxed substrate specificity aromatic ring dioxygenase, toluate 1,2-dioxygenase, encoded by TOL plasmid pWW0 of Pseudomonas putida.
Harayama S, Rekik M, Timmis KN
Mol Gen Genet 1986 Feb;202(2):226-34
PubMed ID: 3010045