Pseudomonas aeruginosa PAO1, PA0651 (trpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004425 indole-3-glycerol-phosphate synthase activity
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
22555873 Reviewed by curator
Biological Process GO:0000162 tryptophan biosynthetic process
IMP
Inferred from Mutant Phenotype
ECO:0000016
loss-of-function mutant phenotype evidence
22555873 Reviewed by curator
Molecular Function GO:0004425 indole-3-glycerol-phosphate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00331
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006568 tryptophan metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00614
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.70
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00400 Phenylalanine, tyrosine and tryptophan biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCyc COMPLETE-ARO-PWY superpathway of aromatic amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc TRPSYN-PWY L-tryptophan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Phenylalanine, tyrosine and tryptophan biosynthesis ECO:0000037
not_recorded
PseudoCyc ALL-CHORISMATE-PWY superpathway of chorismate metabolism 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae00400 Phenylalanine, tyrosine and tryptophan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00218 Indole-3-glycerol phosphate synthase IPR013798 Indole-3-glycerol phosphate synthase 7 263 4.5E-101
Hamap MF_00134_B Indole-3-glycerol phosphate synthase [trpC]. IPR013798 Indole-3-glycerol phosphate synthase 5 265 36.629
CDD cd00331 IGPS IPR013798 Indole-3-glycerol phosphate synthase 43 263 2.34676E-113
ProSitePatterns PS00614 Indole-3-glycerol phosphate synthase signature. IPR001468 Indole-3-glycerol phosphate synthase, conserved site 58 76 -
SUPERFAMILY SSF51366 IPR011060 Ribulose-phosphate binding barrel 14 265 2.0E-86
Gene3D G3DSA:3.20.20.70 IPR013785 Aldolase-type TIM barrel 2 268 3.3E-101

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.