Pseudomonas aeruginosa PAO1, PA3802 (hisS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004814 arginine-tRNA ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044267 cellular protein metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00127
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006427 histidyl-tRNA aminoacylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00127
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43707
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004821 histidine-tRNA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00127
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Translation, post-translational modification, degradation Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00970 Aminoacyl-tRNA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc TRNA-CHARGING-PWY tRNA charging 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.800 - IPR036621 Anticodon-binding domain superfamily 330 425 6.5E-28
NCBIfam TIGR00442 JCVI: histidine--tRNA ligase IPR015807 Histidine-tRNA ligase 6 414 0.0
CDD cd00773 HisRS-like_core IPR041715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 22 318 4.65759E-97
Pfam PF13393 Histidyl-tRNA synthetase IPR041715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 10 313 4.5E-45
PIRSF PIRSF001549 His-tRNA_synth IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit 1 425 1.2E-115
CDD cd00859 HisRS_anticodon IPR033656 Histidyl-anticodon-binding 330 423 4.953E-29
PANTHER PTHR43707 HISTIDYL-TRNA SYNTHETASE IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit 4 416 1.5E-103
SUPERFAMILY SSF52954 Class II aaRS ABD-related - - 330 425 5.4E-23
Pfam PF03129 Anticodon binding domain IPR004154 Anticodon-binding 338 422 2.8E-8
SUPERFAMILY SSF55681 Class II aaRS and biotin synthetases IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 6 323 6.7E-102
Gene3D G3DSA:3.30.930.10 Bira Bifunctional Protein; Domain 2 IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 2 326 1.2E-116
Hamap MF_00127 Histidine--tRNA ligase [hisS]. IPR015807 Histidine-tRNA ligase 3 424 33.279121
FunFam G3DSA:3.30.930.10:FF:000005 Histidine--tRNA ligase - - 2 323 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.