Pseudomonas aeruginosa PAO1, PA4056 (ribD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0042602 riboflavin reductase (NADPH) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 18500821 Reviewed by curator
Molecular Function GO:0019239 deaminase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 18500821 Reviewed by curator
Molecular Function GO:0004746 riboflavin synthase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 18500821 Reviewed by curator
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01872
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00227
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009231 riboflavin biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01872
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53927
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00326
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00740 Riboflavin metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc toxoflavin biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCAP Riboflavin metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.430.10 Dihydrofolate Reductase, subunit A IPR024072 Dihydrofolate reductase-like domain superfamily 143 372 3.3E-68
SUPERFAMILY SSF53597 Dihydrofolate reductase-like IPR024072 Dihydrofolate reductase-like domain superfamily 147 365 1.68E-55
SUPERFAMILY SSF53927 Cytidine deaminase-like IPR016193 Cytidine deaminase-like 5 146 9.03E-49
NCBIfam TIGR00227 JCVI: riboflavin-specific deaminase C-terminal domain IPR011549 Riboflavin-specific deaminase, C-terminal 148 367 1.1E-52
FunFam G3DSA:3.40.140.10:FF:000025 Riboflavin biosynthesis protein RibD - - 2 142 1.3E-67
PIRSF PIRSF006769 RibD IPR004794 Riboflavin biosynthesis protein RibD 1 370 1.6E-127
Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region IPR002125 Cytidine and deoxycytidylate deaminase domain 8 101 1.7E-19
CDD cd01284 Riboflavin_deaminase-reductase - - 9 121 5.23405E-55
Pfam PF01872 RibD C-terminal domain IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal 149 363 5.0E-47
PANTHER PTHR38011 DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820) - - 142 366 2.8E-33
Gene3D G3DSA:3.40.140.10 Cytidine Deaminase, domain 2 - - 2 142 1.9E-47
NCBIfam TIGR00326 JCVI: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD IPR004794 Riboflavin biosynthesis protein RibD 9 364 5.8E-115

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.