Pseudomonas aeruginosa PAO1, PA4091 (hpaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0044248 cellular catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8550403 Reviewed by curator
Biological Process GO:0015976 carbon utilization
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:1901022 4-hydroxyphenylacetate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8550403 Reviewed by curator
Molecular Function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050660 flavin adenine dinucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF56645
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0010124 phenylacetate catabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01220 Degradation of aromatic compounds 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00350 Tyrosine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Aromatic compound catabolism ECO:0000037
not_recorded
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF47203 Acyl-CoA dehydrogenase C-terminal domain-like IPR036250 Acyl-CoA dehydrogenase-like, C-terminal 272 494 6.7E-45
PIRSF PIRSF500125 4_HPA_large IPR024677 4-HPA 3-monooxygenase large component/Pyoverdin chromophore biosynthetic protein 1 518 0.0
SUPERFAMILY SSF56645 Acyl-CoA dehydrogenase NM domain-like IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily 13 282 1.04E-81
Gene3D G3DSA:2.40.110.10 - IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily 156 282 8.7E-41
PANTHER PTHR36117 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED IPR004925 HpaB/PvcC/4-BUDH 6 514 0.0
PIRSF PIRSF000331 HpaA_HpaB IPR004925 HpaB/PvcC/4-BUDH 11 501 0.0
FunFam G3DSA:1.20.140.10:FF:000044 4-hydroxyphenylacetate 3-monooxygenase oxygenase component - - 284 500 1.7E-107
Pfam PF11794 4-hydroxyphenylacetate 3-hydroxylase N terminal IPR024674 HpaB/PvcC/4-BUDH N-terminal 15 280 5.3E-93
FunFam G3DSA:1.10.3140.10:FF:000001 4-hydroxyphenylacetate 3-monooxygenase oxygenase component - - 13 151 6.7E-76
Gene3D G3DSA:1.10.3140.10 - - - 14 155 1.1E-49
Gene3D G3DSA:1.20.140.10 - - - 284 500 4.4E-72
NCBIfam TIGR02310 JCVI: 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component IPR012688 4-hydroxyphenylacetate 3-monooxygenase oxygenase component, gammaproteobacteria 2 520 0.0
FunFam G3DSA:2.40.110.10:FF:000026 4-hydroxyphenylacetate 3-monooxygenase oxygenase component - - 152 282 6.0E-70
Pfam PF03241 4-hydroxyphenylacetate 3-hydroxylase C terminal IPR024719 HpaB/PvcC/4-BUDH C-terminal 288 477 1.5E-58

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.