Pseudomonas aeruginosa PAO1, PA4138 (tyrS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0043039 tRNA aminoacylation
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009094 L-phenylalanine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0000162 tryptophan biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006571 tyrosine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044267 cellular protein metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0000166 nucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00234
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006418 tRNA aminoacylation for protein translation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00579
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004831 tyrosine-tRNA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11766
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004812 aminoacyl-tRNA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00579
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006437 tyrosyl-tRNA aminoacylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00234
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00234
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003723 RNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.10.290.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Translation, post-translational modification, degradation Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00970 Aminoacyl-tRNA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Aminoacyl-tRNA biosynthesis ECO:0000037
not_recorded
PseudoCAP Phenylalanine, tyrosine and tryptophan biosynthesis ECO:0000037
not_recorded
PseudoCyc TRNA-CHARGING-PWY tRNA charging 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.10.290.10 - IPR036986 RNA-binding S4 domain superfamily 333 409 2.4E-11
CDD cd00805 TyrRS_core IPR002307 Tyrosine-tRNA ligase 39 307 1.61809E-100
SUPERFAMILY SSF52374 Nucleotidylyl transferase - - 9 322 1.93E-87
PRINTS PR01040 Tyrosyl-tRNA synthetase signature IPR002307 Tyrosine-tRNA ligase 166 181 1.3E-25
PANTHER PTHR11766 TYROSYL-TRNA SYNTHETASE IPR024088 Tyrosine-tRNA ligase, bacterial-type 6 403 1.5E-109
PRINTS PR01040 Tyrosyl-tRNA synthetase signature IPR002307 Tyrosine-tRNA ligase 220 232 1.3E-25
NCBIfam TIGR00234 JCVI: tyrosine--tRNA ligase IPR002307 Tyrosine-tRNA ligase 8 409 4.0E-96
SUPERFAMILY SSF55174 Alpha-L RNA-binding motif - - 306 409 4.24E-10
Gene3D G3DSA:1.10.240.10 - - - 227 332 2.3E-29
Hamap MF_02006 Tyrosine--tRNA ligase [tyrS]. IPR024107 Tyrosine-tRNA ligase, bacterial-type, type 1 8 410 40.330463
Pfam PF00579 tRNA synthetases class I (W and Y) IPR002305 Aminoacyl-tRNA synthetase, class Ic 36 325 1.5E-66
Gene3D G3DSA:3.40.50.620 HUPs IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 2 226 3.7E-82
FunFam G3DSA:1.10.240.10:FF:000001 Tyrosine--tRNA ligase - - 227 328 2.6E-28
PRINTS PR01040 Tyrosyl-tRNA synthetase signature IPR002307 Tyrosine-tRNA ligase 187 209 1.3E-25
PRINTS PR01040 Tyrosyl-tRNA synthetase signature IPR002307 Tyrosine-tRNA ligase 50 72 1.3E-25

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.