Pseudomonas aeruginosa PAO1, PA4280 (birA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00978
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00121
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0036211 protein modification process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03099
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00780 Biotin metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR12835 BIOTIN PROTEIN LIGASE - - 6 304 3.6E-54
NCBIfam TIGR00121 JCVI: biotin--[acetyl-CoA-carboxylase] ligase IPR004408 Biotin--acetyl-CoA-carboxylase ligase 73 308 8.5E-57
Gene3D G3DSA:1.10.10.10 - IPR036388 Winged helix-like DNA-binding domain superfamily 1 59 1.7E-19
Pfam PF08279 HTH domain IPR013196 Helix-turn-helix, type 11 2 54 1.2E-8
CDD cd16442 BPL IPR004408 Biotin--acetyl-CoA-carboxylase ligase 77 244 4.95701E-64
Pfam PF03099 Biotin/lipoate A/B protein ligase family IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain 80 201 7.1E-22
Gene3D G3DSA:3.30.930.10 Bira Bifunctional Protein; Domain 2 IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 65 261 1.5E-61
Gene3D G3DSA:2.30.30.100 - - - 263 312 1.3E-10
SUPERFAMILY SSF46785 Winged helix DNA-binding domain IPR036390 Winged helix DNA-binding domain superfamily 3 55 4.62E-10
SUPERFAMILY SSF50037 C-terminal domain of transcriptional repressors IPR008988 Transcriptional repressor, C-terminal 263 309 1.28E-6
Hamap MF_00978 Bifunctional ligase/repressor BirA [birA]. IPR030855 Bifunctional ligase/repressor BirA 1 309 32.834602
SUPERFAMILY SSF55681 Class II aaRS and biotin synthetases IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) 71 260 6.84E-60

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.