Pseudomonas aeruginosa PAO1, PA4406 (lpxC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9068651 Reviewed by curator
Biological Process GO:0009245 lipid A biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9068651 Reviewed by curator
Biological Process GO:0009245 lipid A biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.230.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.230.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc KDO-PEP-LIPASYN-PWY KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00540 Lipopolysaccharide biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc NAGLIPASYN-PWY lipid IV<sub>A</sub> biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc KDO-NAGLIPASYN-PWY superpathway of (Kdo)<SUB>2</SUB>-lipid A biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PEP-LIPA-SYN-PWY peptidoglycan and lipid A precursor biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF03331 UDP-3-O-acyl N-acetylglycosamine deacetylase IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase 4 275 2.1E-108
FunFam G3DSA:3.30.1700.10:FF:000001 UDP-3-O-acyl-N-acetylglucosamine deacetylase - - 128 303 5.9E-96
Hamap MF_00388 UDP-3-O-acyl-N-acetylglucosamine deacetylase [lpxC]. IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase 2 279 47.07692
FunFam G3DSA:3.30.230.20:FF:000001 UDP-3-O-acyl-N-acetylglucosamine deacetylase - - 1 127 2.8E-70
Gene3D G3DSA:3.30.230.20 lpxc deacetylase, domain 1 IPR015870 UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal 1 127 4.6E-52
NCBIfam TIGR00325 JCVI: UDP-3-O-acyl-N-acetylglucosamine deacetylase IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase 2 298 2.6E-121
SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like IPR020568 Ribosomal protein uS5 domain 2-type superfamily 3 124 6.98E-43
Gene3D G3DSA:3.30.1700.10 lpxc deacetylase, domain 2 IPR011334 UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal 128 303 2.6E-73
PANTHER PTHR33694 UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE 1, MITOCHONDRIAL-RELATED IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase 3 284 1.4E-90
SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like IPR020568 Ribosomal protein uS5 domain 2-type superfamily 134 277 1.82E-52

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.