Pseudomonas aeruginosa PAO1, PA4410 (ddlB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008716 D-alanine-D-alanine ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1993184 Reviewed by curator
Molecular Function GO:0008716 D-alanine-D-alanine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF039102
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF039102
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF039102
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PEPTIDOGLYCANSYN-PWY peptidoglycan biosynthesis I (meso-diaminopimelate containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01502 Vancomycin resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc KDO-PEP-LIPASYN-PWY KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00473 D-Alanine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Peptideglycan biosynthesis ECO:0000037
not_recorded
KEGG pae00550 Peptidoglycan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PEP-LIPA-SYN-PWY peptidoglycan and lipid A precursor biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.1490.20:FF:000007 D-alanine--D-alanine ligase - - 127 192 5.5E-21
Pfam PF07478 D-ala D-ala ligase C-terminus IPR011095 D-alanine--D-alanine ligase, C-terminal 120 311 2.6E-57
PANTHER PTHR23132 D-ALANINE--D-ALANINE LIGASE - - 67 316 4.3E-68
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 20 112 5.08E-30
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 113 312 5.48E-59
PIRSF PIRSF039102 Ddl/VanB IPR005905 D-alanine--D-alanine ligase 17 65 7.6E-8
Gene3D G3DSA:3.30.470.20 - - - 101 314 3.3E-50
PIRSF PIRSF039102 Ddl/VanB IPR005905 D-alanine--D-alanine ligase 59 318 1.2E-82
Pfam PF01820 D-ala D-ala ligase N-terminus IPR011127 D-alanine--D-alanine ligase, N-terminal domain 68 102 1.8E-10
Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. IPR005905 D-alanine--D-alanine ligase 19 315 35.05431
FunFam G3DSA:3.40.50.20:FF:000013 D-alanine--D-alanine ligase - - 16 100 3.1E-35
NCBIfam TIGR01205 JCVI: D-alanine--D-alanine ligase IPR005905 D-alanine--D-alanine ligase 20 313 1.6E-109
Gene3D G3DSA:3.40.50.20 - - - 8 100 9.3E-29
Gene3D G3DSA:3.30.1490.20 - IPR013815 ATP-grasp fold, subdomain 1 128 192 3.3E-26
FunFam G3DSA:3.30.470.20:FF:000008 D-alanine--D-alanine ligase - - 157 311 6.6E-41

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.