Pseudomonas aeruginosa PAO1, PA4411 (murC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53623
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00046
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009058 biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.90.190.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016881 acid-amino acid ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.90.190.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PEPTIDOGLYCANSYN-PWY peptidoglycan biosynthesis I (meso-diaminopimelate containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PEP-LIPA-SYN-PWY peptidoglycan and lipid A precursor biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-DAP-containing) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00471 D-Glutamine and D-glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Peptideglycan biosynthesis ECO:0000037
not_recorded
PseudoCyc KDO-PEP-LIPASYN-PWY KDO<SUB>2</SUB>-lipid A and peptidoglycan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00550 Peptidoglycan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF53244 MurD-like peptide ligases, peptide-binding domain IPR036615 Mur ligase, C-terminal domain superfamily 319 468 8.79E-47
FunFam G3DSA:3.40.1190.10:FF:000001 UDP-N-acetylmuramate--L-alanine ligase - - 104 320 6.6E-109
Hamap MF_00046 UDP-N-acetylmuramate--L-alanine ligase [murC]. IPR005758 UDP-N-acetylmuramate--L-alanine ligase 15 472 43.895645
SUPERFAMILY SSF51984 MurCD N-terminal domain - - 16 102 4.05E-29
NCBIfam TIGR01082 JCVI: UDP-N-acetylmuramate--L-alanine ligase IPR005758 UDP-N-acetylmuramate--L-alanine ligase 17 466 0.0
SUPERFAMILY SSF53623 MurD-like peptide ligases, catalytic domain IPR036565 Mur-like, catalytic domain superfamily 101 318 1.27E-74
Pfam PF02875 Mur ligase family, glutamate ligase domain IPR004101 Mur ligase, C-terminal 320 410 9.2E-21
Gene3D G3DSA:3.40.50.720 - - - 7 102 1.3E-33
Gene3D G3DSA:3.40.1190.10 - IPR036565 Mur-like, catalytic domain superfamily 104 321 9.9E-69
Gene3D G3DSA:3.90.190.20 - IPR036615 Mur ligase, C-terminal domain superfamily 322 473 1.2E-53
Pfam PF01225 Mur ligase family, catalytic domain IPR000713 Mur ligase, N-terminal catalytic domain 17 115 4.6E-30
Pfam PF08245 Mur ligase middle domain IPR013221 Mur ligase, central 120 299 4.1E-27
PANTHER PTHR43445 UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE-RELATED - - 12 468 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.