Pseudomonas aeruginosa PAO1, PA4448 (hisD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004399 histidinol dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3018428 Reviewed by curator
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd06572
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd06572
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53720
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd06572
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004399 histidinol dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000099
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0000105 histidine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000099
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Histidine metabolism ECO:0000037
not_recorded
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00340 Histidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc HISTSYN-PWY L-histidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain - - 240 358 0.0
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 143 169 2.7E-88
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 177 203 2.7E-88
FunFam G3DSA:1.20.5.1300:FF:000002 Histidinol dehydrogenase, chloroplastic - - 393 436 5.6E-16
PIRSF PIRSF000099 Histidinol_dh IPR022695 Histidinol dehydrogenase, monofunctional 8 436 0.0
FunFam G3DSA:3.40.50.1980:FF:000004 Histidinol dehydrogenase - - 35 243 1.2E-113
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 327 352 2.7E-88
PANTHER PTHR21256 HISTIDINOL DEHYDROGENASE HDH IPR012131 Histidinol dehydrogenase 20 436 0.0
Gene3D G3DSA:1.20.5.1300 - - - 393 436 3.2E-8
NCBIfam TIGR00069 JCVI: histidinol dehydrogenase IPR012131 Histidinol dehydrogenase 39 433 0.0
Pfam PF00815 Histidinol dehydrogenase IPR012131 Histidinol dehydrogenase 30 433 0.0
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 236 257 2.7E-88
Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain - - 35 392 0.0
FunFam G3DSA:3.40.50.1980:FF:000010 Histidinol dehydrogenase - - 244 358 6.1E-54
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 207 232 2.7E-88
SUPERFAMILY SSF53720 ALDH-like IPR016161 Aldehyde/histidinol dehydrogenase 33 434 2.35E-86
Hamap MF_01024 Histidinol dehydrogenase [hisD]. IPR012131 Histidinol dehydrogenase 10 435 73.425613
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 39 63 2.7E-88
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 368 386 2.7E-88
PRINTS PR00083 Histidinol dehydrogenase signature IPR012131 Histidinol dehydrogenase 258 277 2.7E-88
CDD cd06572 Histidinol_dh IPR012131 Histidinol dehydrogenase 35 426 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.