Pseudomonas aeruginosa PAO1, PA4598 (mexD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0042493 response to drug
EXP
Inferred from Experiment 		ECO:0000269
experimental evidence used in manual assertion		 12654738 Reviewed by curator
Cellular Component GO:0016020 membrane
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006810 transport
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0042910 xenobiotic transmembrane transporter activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 8878035 Reviewed by curator
Biological Process GO:0006811 ion transport
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion
Biological Process GO:0046677 response to antibiotic
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0015562 efflux transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042908 xenobiotic transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Membrane proteins Other PAO1 genes in this class
Transport of small molecules Other PAO1 genes in this class
Antibiotic resistance and susceptibility Other PAO1 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR32063 - IPR001036 Acriflavin resistance protein 2 1027 0.0
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 7 517 0.0
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 148 332 4.24E-21
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 298 499 1.05E-49
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 721 806 5.36E-20
FunFam G3DSA:1.20.1640.10:FF:000001 Efflux pump membrane transporter - - 323 512 4.9E-71
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 554 571 9.0E-100
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 518 1021 0.0
NCBIfam TIGR00915 JCVI: efflux RND transporter permease subunit IPR004764 Multidrug resistance protein MdtF-like 1 1038 0.0
FunFam G3DSA:3.30.70.1430:FF:000001 Efflux pump membrane transporter - - 38 135 1.2E-28
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 365 386 9.0E-100
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 182 280 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 621 635 9.0E-100
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 393 417 9.0E-100
Gene3D G3DSA:3.30.70.1440 Multidrug efflux transporter AcrB pore domain - - 671 869 0.0
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 1 1023 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 447 470 9.0E-100
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 38 819 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 338 361 9.0E-100
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 36 54 9.0E-100
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 723 811 0.0
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 185 274 3.53E-20
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 472 495 9.0E-100
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 567 670 4.03E-24
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 38 129 2.09E-23
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 572 670 0.0
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 804 1026 6.28E-47
Gene3D G3DSA:3.30.70.1320 Multidrug efflux transporter AcrB pore domain like - - 133 333 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 8 32 9.0E-100

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.