Pseudomonas aeruginosa PAO1, PA4733 (acsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0015976 carbon utilization
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044248 cellular catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0008152 metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019541 propionate metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004822 isoleucine-tRNA ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0016208 AMP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01123
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003987 acetate-CoA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01123
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019427 acetyl-CoA biosynthetic process from acetate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01123
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc lupulone and humulone biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY0-1313 acetate conversion to acetyl-CoA 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
MetaCyc <i>cis</i>-genanyl-CoA degradation InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc colupulone and cohumulone biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCAP Propanoate metabolism ECO:0000037
not_recorded
MetaCyc adlupulone and adhumulone biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc L-isoleucine biosynthesis V InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00010 Glycolysis / Gluconeogenesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00640 Propanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc chitin degradation to ethanol InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00680 Methane metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ACETATEUTIL-PWY superpathway of acetate utilization and formation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Reductive carboxylate cycle (CO2 fixation) ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR24095 ACETYL-COENZYME A SYNTHETASE - - 20 641 0.0
NCBIfam TIGR02188 JCVI: acetate--CoA ligase IPR011904 Acetate-CoA ligase 20 640 0.0
Gene3D G3DSA:3.40.50.12780 - IPR042099 ANL, N-terminal domain 2 514 0.0
Pfam PF00501 AMP-binding enzyme IPR000873 AMP-dependent synthetase/ligase domain 83 519 6.7E-92
FunFam G3DSA:3.30.300.30:FF:000004 Acetyl-coenzyme A synthetase - - 515 645 1.5E-59
Gene3D G3DSA:3.30.300.30 - IPR045851 AMP-binding enzyme, C-terminal domain superfamily 515 644 4.2E-32
CDD cd05966 ACS - - 22 631 0.0
SUPERFAMILY SSF56801 Acetyl-CoA synthetase-like - - 11 637 0.0
Hamap MF_01123 Acetyl-coenzyme A synthetase [acs]. IPR011904 Acetate-CoA ligase 2 642 53.941422
Pfam PF13193 AMP-binding enzyme C-terminal domain IPR025110 AMP-binding enzyme, C-terminal domain 528 606 8.3E-24
FunFam G3DSA:3.40.50.12780:FF:000001 Acetyl-coenzyme A synthetase - - 5 514 0.0
Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain 24 80 9.7E-22

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.