Pseudomonas aeruginosa PAO1, PA4758 (carA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0071230 cellular response to amino acid stimulus
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 8169201 Reviewed by curator
Molecular Function GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01209
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006541 glutamine metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01209
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01209
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded
PseudoCyc ARGSYNBSUB-PWY L-arginine biosynthesis II (acetyl cycle) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-5686 UMP biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00250 Alanine, aspartate and glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 264 280 5.3E-39
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 281 298 5.3E-39
PRINTS PR00097 Anthranilate synthase component II signature - - 349 362 1.1E-5
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 236 245 3.1E-11
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 233 247 5.3E-39
FunFam G3DSA:3.40.50.880:FF:000011 Carbamoyl-phosphate synthase small chain - - 152 378 2.9E-130
Gene3D G3DSA:3.50.30.20 - IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily 2 151 1.9E-63
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 306 317 5.3E-39
Gene3D G3DSA:3.40.50.880 - IPR029062 Class I glutamine amidotransferase-like 152 377 2.7E-81
FunFam G3DSA:3.50.30.20:FF:000001 Carbamoyl-phosphate synthase small chain - - 2 151 8.8E-66
Pfam PF00117 Glutamine amidotransferase class-I IPR017926 Glutamine amidotransferase 197 372 1.8E-46
Pfam PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain 7 132 2.4E-50
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 194 208 5.3E-39
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 349 362 3.1E-11
Hamap MF_01209 Carbamoyl-phosphate synthase small chain [carA]. IPR006274 Carbamoyl-phosphate synthase, small subunit 3 378 47.7276
PRINTS PR00097 Anthranilate synthase component II signature - - 264 275 1.1E-5
SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like IPR029062 Class I glutamine amidotransferase-like 153 377 3.21E-62
SMART SM01097 CPSase_sm_chain_2 IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain 3 133 8.9E-92
CDD cd01744 GATase1_CPSase IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain 194 371 1.93367E-111
SUPERFAMILY SSF52021 Carbamoyl phosphate synthetase, small subunit N-terminal domain IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily 4 144 1.96E-56
PANTHER PTHR11405 CARBAMOYLTRANSFERASE FAMILY MEMBER - - 3 360 4.0E-53
NCBIfam TIGR01368 JCVI: glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit IPR006274 Carbamoyl-phosphate synthase, small subunit 5 375 0.0
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 264 275 3.1E-11
PRINTS PR00097 Anthranilate synthase component II signature - - 236 245 1.1E-5

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.