Pseudomonas aeruginosa PAO1, PA4855 (purD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006163 purine nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004637 phosphoribosylamine-glycine ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02843
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.1490.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009113 purine nucleobase biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02843
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF02843 Phosphoribosylglycinamide synthetase, C domain IPR020560 Phosphoribosylglycinamide synthetase, C-domain 330 420 7.8E-32
SMART SM01209 GARS_A_3 - - 102 295 0.0
Gene3D G3DSA:3.90.600.10 - IPR037123 Phosphoribosylglycinamide synthetase, C-domain superfamily 330 428 1.8E-37
FunFam G3DSA:3.40.50.20:FF:000006 Phosphoribosylamine--glycine ligase, chloroplastic - - 2 94 4.0E-38
PANTHER PTHR43472 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE IPR000115 Phosphoribosylglycinamide synthetase 1 425 0.0
Gene3D G3DSA:3.40.50.20 - - - 2 94 8.3E-36
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 1 102 1.18E-34
Pfam PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 102 295 2.4E-82
FunFam G3DSA:3.30.1490.20:FF:000006 phosphoribosylamine--glycine ligase, chloroplastic-like - - 120 189 5.8E-32
NCBIfam TIGR00877 JCVI: phosphoribosylamine--glycine ligase IPR000115 Phosphoribosylglycinamide synthetase 1 422 0.0
Gene3D G3DSA:3.30.1490.20 - IPR013815 ATP-grasp fold, subdomain 1 120 189 9.6E-31
FunFam G3DSA:3.30.470.20:FF:000031 Phosphoribosylamine--glycine ligase - - 190 328 1.6E-78
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 103 319 5.13E-64
Gene3D G3DSA:3.30.470.20 - - - 190 328 1.4E-58
SUPERFAMILY SSF51246 Rudiment single hybrid motif IPR011054 Rudiment single hybrid motif 328 423 2.04E-33
Pfam PF02844 Phosphoribosylglycinamide synthetase, N domain IPR020562 Phosphoribosylglycinamide synthetase, N-terminal 1 101 4.8E-36
FunFam G3DSA:3.90.600.10:FF:000001 Trifunctional purine biosynthetic protein adenosine-3 - - 329 429 7.3E-39
Hamap MF_00138 Phosphoribosylamine--glycine ligase [purD]. IPR000115 Phosphoribosylglycinamide synthetase 1 422 43.447395
SMART SM01210 GARS_C_2 IPR020560 Phosphoribosylglycinamide synthetase, C-domain 329 422 3.2E-55

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.